In liver transplant surgery, the major sites of blood loss are at the site of anastomosis of the inferior vena cava, portal vein, and hepatic artery. Further, the patient is typically heparinized during the procedure to avoid blood clots in these vessels. SeraSeal™ is very effective to achieve haemostasis within seconds, even in the presence of heparin. Currently available haemostatic agents are ineffective in heparinized blood. When the patient is on heparin, SeraSeal™ ‘s Factor Vlla will catalyze the extrinsic pathway, Factor IXa the intrinsic pathway, and Factor Xa and 11a the common coagulation pathway to the blood lost at the wound site.It is recommended to apply drops of SeraSeal™ completely around the site of the anastomosis, to prevent leaking, before the clamp is removed. This is a cautionary step before the clamp is removed and blood flow is restored, particularly the hepatic artery. Once the clamp is removed, it is not uncommon for some bleeding to accrue at the site of anastomosis. Should this happen, apply another dropwise application of SeraSeal™ to seal the wound.
During Liver resection, cauterization would not be effective, because liver being a highly vascular organ, would be observed to crack and re-bleed. Damaged tissues or nerves cannot be replaced, additionally if not removed would cause infection and inflammation. Therefore Seraseal™ would be highly effective in reduction of anti-inflammatory drugs, pain management drugs and reduction of antibiotics. Also Seraseal™ special feature is that is does not get absorbed into the intravascular system. Therefore it will not cause DIC(Disseminated Intravascular Coagulation). Clinical trial studies have shown SeraSeal™ can reduce surgical time by as much as 50% and blood loss reduction by 90% in upto 40% surgical procedures.